Category Archives: Glutathione

What is Glutathione (GSH)?

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If you’re reading this, odds are you have seen the term “Glutathione” (GSH) before. But how much do you know about this powerful antioxidant? Do you know that it has been touted as the “next big antioxidant” or “the master defender” by health professionals world wide? If not, listen up.

Glutathione offers countless benefits related to joints, eyes, the brain and lungs. Yet, market research suggests that fewer than 6% of consumers are familiar with it. How could this be?

GSH is the most prevalent antioxidant produced by the human body. Healthy cells actually produce Glutathione. When cells run out of GSH, they die! GSH production naturally declines with age. So, supplementation of this vital antioxidant is paramount.

Glutathione

  • Helps protect cells from the damage caused by harmful free radicals
  • Promotes detoxification and optimal cellular health
  • Supports a healthy liver and immune system

Glutathione deficiencies have been linked to many chronic, difficult to treat illnesses. (Here is your chance to start that online search we mentioned earlier!). In addition to its powerful effects inside the body, Glutathione has been used for decades all over the world to improve skin clarity, tone and texture.

A study published in the European Journal of Nutrition revealed that daily supplementation of Setria® Glutathione – the form of L-Glutathione used in Lypo-Spheric™ Glutathione – is effective at increasing body stores of Glutathione by 30-35% over a 6 month period.

It’s probably time for you to give Gluathione a try. With our 100% money back guarantee, what have you got to lose?

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Study Shows Daily Supplementation of Setria® Glutathione Increases Glutathione Levels in the Body

glutathione supplement

A new study published in the European Journal of Nutrition revealed that daily supplementation of Setria® Glutathione – the form of L-Glutathione used in Lypo-Spheric™ GSH – is effective at increasing body stores of glutathione by 30-35% over a 6 month period.

The randomized, double-blind, placebo-controlled trial was conducted at Penn State University School of Medicine and lead by Dr. John P. Richie, Jr., Ph.D., Professor of Public Health Sciences and Pharmacology. Dr. Richie has studied glutathione for more than 25 years, focusing primarily on glutathione’s ability to fight oxidative stress.

“It is well-known in the science community that glutathione is one of the primary protective molecules in the body; however, whether or not glutathione levels could be supplemented by oral glutathione administration has been hotly debated and clinical data has been lacking,” said Dr. Richie. “Now we have evidence to illustrate the potential benefit of glutathione supplementation …”

The study measured the effect of supplementation with Setria® Glutathione on glutathione levels in 54 healthy adults, 28-72 years of age. One group of subjects took 250 mg/day (low-dose), the second group took 1,000 mg/day (high-dose), and the third group took 470 mg/day of placebo. Glutathione levels were measured over a six month period in different blood components, including erythrocytes (red blood cells) and lymphocytes (white blood cells), as well as the buccal mucosal cells that line the inside of the cheeks.

Results of the study showed glutathione levels in the blood increased after one, three and six months when compared to baseline levels at both doses.And at six months, average glutathione levels increased 30-35% in erythrocytes, plasma, and lymphocytes, and 260% in buccal cells in the high-dose group.

In addition to the increase in glutathione levels, the study showed that daily supplementation of 1,000 mg/day enhanced the function of natural killer (NK) cells more than two fold after three months. NK cells are vital to a well-functioning immune system because they can rapidly identify and kill abnormal cells. This two fold increase in NK cytotoxicity means the NK cells were two times as effective at killing abnormal cells, such as cells that are virally infected or tumorigenic.

A secondary endpoint analysis of the data also indicated that daily supplementation of 250 mg – 1,000 mg of Setria® Glutathione may result in a significant decrease in oxidative stress after 6 months. While the majority of glutathione in cells is in the reduced form (the “active” form), it becomes oxidized when it is used to neutralize free radicals and other toxins that cause oxidative stress.  So as oxidative stress increases, the level of oxidized glutathione in the body increases, and the level of reduced glutathione in the body decreases. Therefore, a reduction in oxidative stress was demonstrated with a decrease in the ratio of oxidized to reduced glutathione.

Why is all of this data important?

Glutathione is often called the “Master Defender” due to its vast functions as an antioxidant, detoxifier and immune system supporter. It is found in nearly all cells, tissues and organ systems in the body. Our bodies produce glutathione naturally, but everyday factors including the intake of medication, ill health, exposure to environmental toxins, aging and diet dramatically reduce the body’s stores of glutathione. As glutathione levels decrease, a detrimental drop occurs in the cellular functions that help maintain a healthy heart, brain, eyes, liver, kidneys, pancreas, and joints.

Previously, the only reliable way to boost glutathione levels was with IV infusions. With Setria® Glutathione and the superior bioavailability offered by liposome-encapsulation, this is no longer the case. Orally-ingested Lypo-Spheric™ GSH combines Setria® Glutathione with Liposomal Encapsulation Technology to protect the glutathione from being destroyed in the digestive system, making Lypo-Spheric™ GSH an efficient and cost-effective way to boost glutathione levels.

References

  • Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2014 May 5. PubMed PMID: 24791752.
  • Suntres ZE. Liposomal Antioxidants for Protection against Oxidant-Induced Damage. Journal of Toxicology 2011 May 24. Article ID 152474.
  • Topham NJ, Hewitt, EW. Natural killer cell cytotoxicity: how do they pull the trigger? Immunology. 2009 Sep. PubMed PMCID: 2747134.

Setria® is a registered trademark of Kyowa Hakko USA, Inc.

© 2014 LivOn Labs

Foods High in Glutathione

People are always looking for ways to maintain their health, decrease unwelcome symptoms of aging and boost their immune systems. While a variety of vitamins and minerals can help with some of these functions, there is one nutrient that can help with them all. That nutrient is glutathione, which can be found in a variety of foods. Here are some foods high in glutathione.

Glutathione is a combination of three amino acids known as glutamine, glycine and cysteine. Amino acids are the precursors of proteins. Usually there is a gene in the body that produces an enzyme that combines these amino acids into glutathione. However, this gene does not work correctly in some people. The reasons for this are manifold. For example, it may stop working due to a serious illness. Much of the time, it stops working due to the increased workload on the body’s immune system, such as from air and water pollution and toxins in processed foods. Toxins, such as mercury and lead, can also build up in the body through fish and other foods. Other ways that glutathione levels are decreased include medicines, increased stress and radiation. Even the normal aging process decreases this molecule.

Glutathione is an antioxidant. Without it, the body has great difficulty removing toxins from the blood and from cells in the organs and the skin. Antioxidants decrease the negative effect of free radicals on the cells within the body. Without antioxidants, every cell in the body will readily show the effects of age. Glutathione can also help detoxify the body because the sulfur molecules within glutathione attach to toxins, or poisons, in the body and carry them out as waste products.

A glutathione deficiency may make individuals feel run down. It can leave them with headaches and fatigue. As the body ages, it cannot replenish its supplies of glutathione as well as it once did. Therefore, people must be sure to eat foods high in this molecule to protect their immune systems.

One of the easiest ways to get glutathione from foods is to eat fresh fruits and vegetables. Many of these foods contain some level of glutathione, and those that are raised naturally without chemicals and picked at the peak of ripeness are the best. Fruits that have the highest levels of glutathione include:

  • Apples
  • Bananas
  • Peaches
  • Melons

The best vegetables include:

  • Green peppers
  • Potatoes
  • carrots
  • squash
  • broccoli
  • Spinach

Dark green vegetables are typically rich in sulfur and are therefore rich in glutathione. Milk thistle in a tea, eaten as a seed or sprinkled as a powder, is a great source of glutathione as well.

The second easiest way to consume glutathione is by eating meats and dairy products. Of course, cooking meats decreases the levels of this nutrient; however, there are still smaller levels of glutathione available even after the food is processed or cooked. Beef, chicken, pork, milk and eggs all contain some glutathione.

Selenium and alpha lipoic acid must be consumed as well in order for glutathione to be used in the body. Foods containing selenium include:

  • nuts
  • legumes
  • red meat
  • poultry and cheese

Alpha lipoic acid can be found in several vegetables, including spinach and tomatoes.

Those who are not getting enough glutathione in their diets should consider supplements. These supplements will fill in the gaps in nutrition and may bolster the immune system. As an antioxidant, glutathione is a vital part of anyone’s diet.

Glutathione (GSH) and Electron Flow

GSH and Cellular Health. Glutathione (GSH) is so important to the health of every cell in the body that cells die, when GSH levels inside cells drop too low 1.  It is at this very cellular level where most of the battles against toxins, pathogens, free-radicals, and aging are won or lost.

Even without the extra toxic demands exerted by 21st century living, the requirement for GSH production is high. Immune system cells like mast cells and white blood cells, as well as organ tissues – most notably the brain, heart, lungs, liver, and eyes – depend on GSH for survival. Healthy, unchallenged cells can produce a sufficient amount of GSH for a host of protective (see Table 1.1) and metabolic (see Table 1.2) functions. When additional pressures ensue — like emotional and physical stress, radiation, infection, an unhealthy diet, toxins, heavy metals, and the invasion of pathogens — cellular levels of GSH can be quickly depleted.

Table 1.1 Cell-Protective Functions of GSH
Neutralization and reduction of various toxins and carcinogens
Protection against intracellular oxidative damage
Enhancement and support of the immune system

As long as sufficient quantities of it are present, GSH effectively defends the cell’s DNA, membranes, nucleus, and other organelles by neutralizing this continuous oxidative stress. When GSH is depleted, however, cellular damage can be expected.

Table 1.2 Cell-Metabolic Functions of GSH
Facilitating DNA synthesis and repair
Facilitating protein and prostaglandin synthesis
Facilitating amino acid transport across cell
membranes
Activation of enzymes (includes glutathione reductase, glutathione peroxidase, and glutathione S-transferase) Czeczot 2006

The Miraculous GSH Molecule

The unique molecular characteristics of GSH account for its vast range of functions. In addition to its role as an electron donor (antioxidant), GSH also joins with a large number of different compounds to form complexes (conjugates) with very special properties. This conjugating ability allows GSH to function as a:

  • potent antioxidant
  • powerful detoxifier as the primary participant in the neutralization and/or excretion of many toxins
  • “Super food” for the immune system including B-cells, T-cells, mast cells, phagocytes, and macrophages
  • intracellular source of organic sulfur
  • cofactor for the function of different critical enzymes
  • participant in maintaining integrity of protein’s critical disulfide bonds
  • transporter of amino acids across cell membranes
  • DNA synthesis and repair
  • protein synthesis
  • electron exchanger in many redox reactions

Electron Flow: Key to Continuous Intracellular Defense. The amazing power of GSH, in large part, lies in its ability to promote a healthy flow and supply of electrons within each cell in the body. Even though it is not possible to take a teaspoon of electrons, one can ingest medications and/or nutrients that are extremely rich in their electron content. Once a sufficient quantity of electrons is delivered to the body, it brings about what can only be described as fantastic results.

For more information on Glutathione, read Dr. Thomas Levy’s book GSH Master Defender.

 

Beaver 1995, Ghibelli 1998, Hammond 2004, Franco 2006

What is Reduced Glutathione?

Anyone who has seen iron or steel “rust” has seen the results of oxidation. It is a well-known example of oxidation, and oxygen is actually the culprit in rust, scientists continue to use the term “oxidized” to describe a molecular process which does not always involve oxygen.

Electrons are small, negatively charged particles that orbit the nucleus of the cell. Sound familiar from grade school? Never though this would have been useful in the real world but it is. Each atom has a nucleus which contains positively charged protons and usually neutrally charged neutrons.diagram of an atom

When the number of protons and electrons are equal, the net electrical charge is zero and the molecule is in a stable state. When a molecule has fewer electrons than protons, the net charge is positive and is considered “oxidized”. Oxidized molecules are unstable and seek sufficient electrons to become electrically neutral. These aggressively active molecules are known as free radicals.

Reduced Glutathione

Substances such as vitamin C, in the oxidized state no longer function as an antioxidant. Only when they are reduced, meaning they contain needed electrons, can they effectively function as antioxidants. To learn more about free radicals and Glutathione (GSH). See Dr. Thomas Levy’s book GSH Master Defender Against Disease, Toxins, and Aging.

Pure & Powerful… Lypo-Spheric Supplements

What makes Lypo-Spheric™ products unique? Each Lypo-Spheric™ product is formulated with one goal in mind: to provide you with effective doses of nutrients without the use of binders, fillers, artificial colors or artificial flavors.

The nutrient-filled liposomes in each Lypo-Spheric™ product are small enough – and smart enough – to bypass the body’s restrictive nutrient transport system, and quickly pass through the intestinal wall and into the bloodstream. Within minutes of taking a Lypo-Spheric™ product, millions of liposomes will start to move from your bloodstream and into your cells – intact, and ready to work.

Our single-dose packaging protects the product from additional oxygen and moisture, which keeps your product fresh.

LivOn Labs’ products are sugar free, caffeine free, dairy free, meat free and gluten free.

We source ingredients from all over the world so we can use high-potency, non-GMO ingredients from natural sources whenever possible. We now guarantee that our Lypo-Spheric™ Vitamin C, Lypo-Spheric™ R-ALA and Lypo-Spheric™ GSH are 100% non-GMO.

EXTENDING THE SHELF LIFE….

The shelf life on the majority of our nutritional supplements is 12-18 months. To extend the shelf life we recommend refrigeration for maximum effectiveness. Do not freeze or place the products in direct sunlight for extended periods of time.