Glutathione (GSH) and Electron Flow

GSH and Cellular Health. Glutathione (GSH) is so important to the health of every cell in the body that cells die, when GSH levels inside cells drop too low 1.  It is at this very cellular level where most of the battles against toxins, pathogens, free-radicals, and aging are won or lost.

Even without the extra toxic demands exerted by 21st century living, the requirement for GSH production is high. Immune system cells like mast cells and white blood cells, as well as organ tissues – most notably the brain, heart, lungs, liver, and eyes – depend on GSH for survival. Healthy, unchallenged cells can produce a sufficient amount of GSH for a host of protective (see Table 1.1) and metabolic (see Table 1.2) functions. When additional pressures ensue — like emotional and physical stress, radiation, infection, an unhealthy diet, toxins, heavy metals, and the invasion of pathogens — cellular levels of GSH can be quickly depleted.

Table 1.1 Cell-Protective Functions of GSH
Neutralization and reduction of various toxins and carcinogens
Protection against intracellular oxidative damage
Enhancement and support of the immune system

As long as sufficient quantities of it are present, GSH effectively defends the cell’s DNA, membranes, nucleus, and other organelles by neutralizing this continuous oxidative stress. When GSH is depleted, however, cellular damage can be expected.

Table 1.2 Cell-Metabolic Functions of GSH
Facilitating DNA synthesis and repair
Facilitating protein and prostaglandin synthesis
Facilitating amino acid transport across cell
membranes
Activation of enzymes (includes glutathione reductase, glutathione peroxidase, and glutathione S-transferase) Czeczot 2006

The Miraculous GSH Molecule

The unique molecular characteristics of GSH account for its vast range of functions. In addition to its role as an electron donor (antioxidant), GSH also joins with a large number of different compounds to form complexes (conjugates) with very special properties. This conjugating ability allows GSH to function as a:

  • potent antioxidant
  • powerful detoxifier as the primary participant in the neutralization and/or excretion of many toxins
  • “Super food” for the immune system including B-cells, T-cells, mast cells, phagocytes, and macrophages
  • intracellular source of organic sulfur
  • cofactor for the function of different critical enzymes
  • participant in maintaining integrity of protein’s critical disulfide bonds
  • transporter of amino acids across cell membranes
  • DNA synthesis and repair
  • protein synthesis
  • electron exchanger in many redox reactions

Electron Flow: Key to Continuous Intracellular Defense. The amazing power of GSH, in large part, lies in its ability to promote a healthy flow and supply of electrons within each cell in the body. Even though it is not possible to take a teaspoon of electrons, one can ingest medications and/or nutrients that are extremely rich in their electron content. Once a sufficient quantity of electrons is delivered to the body, it brings about what can only be described as fantastic results.

For more information on Glutathione, read Dr. Thomas Levy’s book GSH Master Defender.

 

Beaver 1995, Ghibelli 1998, Hammond 2004, Franco 2006

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