Study Shows Daily Supplementation of Setria® Glutathione Increases Glutathione Levels in the Body

glutathione supplement

A new study published in the European Journal of Nutrition revealed that daily supplementation of Setria® Glutathione – the form of L-Glutathione used in Lypo-Spheric™ GSH – is effective at increasing body stores of glutathione by 30-35% over a 6 month period.

The randomized, double-blind, placebo-controlled trial was conducted at Penn State University School of Medicine and lead by Dr. John P. Richie, Jr., Ph.D., Professor of Public Health Sciences and Pharmacology. Dr. Richie has studied glutathione for more than 25 years, focusing primarily on glutathione’s ability to fight oxidative stress.

“It is well-known in the science community that glutathione is one of the primary protective molecules in the body; however, whether or not glutathione levels could be supplemented by oral glutathione administration has been hotly debated and clinical data has been lacking,” said Dr. Richie. “Now we have evidence to illustrate the potential benefit of glutathione supplementation …”

The study measured the effect of supplementation with Setria® Glutathione on glutathione levels in 54 healthy adults, 28-72 years of age. One group of subjects took 250 mg/day (low-dose), the second group took 1,000 mg/day (high-dose), and the third group took 470 mg/day of placebo. Glutathione levels were measured over a six month period in different blood components, including erythrocytes (red blood cells) and lymphocytes (white blood cells), as well as the buccal mucosal cells that line the inside of the cheeks.

Results of the study showed glutathione levels in the blood increased after one, three and six months when compared to baseline levels at both doses.And at six months, average glutathione levels increased 30-35% in erythrocytes, plasma, and lymphocytes, and 260% in buccal cells in the high-dose group.

In addition to the increase in glutathione levels, the study showed that daily supplementation of 1,000 mg/day enhanced the function of natural killer (NK) cells more than two fold after three months. NK cells are vital to a well-functioning immune system because they can rapidly identify and kill abnormal cells. This two fold increase in NK cytotoxicity means the NK cells were two times as effective at killing abnormal cells, such as cells that are virally infected or tumorigenic.

A secondary endpoint analysis of the data also indicated that daily supplementation of 250 mg – 1,000 mg of Setria® Glutathione may result in a significant decrease in oxidative stress after 6 months. While the majority of glutathione in cells is in the reduced form (the “active” form), it becomes oxidized when it is used to neutralize free radicals and other toxins that cause oxidative stress.  So as oxidative stress increases, the level of oxidized glutathione in the body increases, and the level of reduced glutathione in the body decreases. Therefore, a reduction in oxidative stress was demonstrated with a decrease in the ratio of oxidized to reduced glutathione.

Why is all of this data important?

Glutathione is often called the “Master Defender” due to its vast functions as an antioxidant, detoxifier and immune system supporter. It is found in nearly all cells, tissues and organ systems in the body. Our bodies produce glutathione naturally, but everyday factors including the intake of medication, ill health, exposure to environmental toxins, aging and diet dramatically reduce the body’s stores of glutathione. As glutathione levels decrease, a detrimental drop occurs in the cellular functions that help maintain a healthy heart, brain, eyes, liver, kidneys, pancreas, and joints.

Previously, the only reliable way to boost glutathione levels was with IV infusions. With Setria® Glutathione and the superior bioavailability offered by liposome-encapsulation, this is no longer the case. Orally-ingested Lypo-Spheric™ GSH combines Setria® Glutathione with Liposomal Encapsulation Technology to protect the glutathione from being destroyed in the digestive system, making Lypo-Spheric™ GSH an efficient and cost-effective way to boost glutathione levels.


  • Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2014 May 5. PubMed PMID: 24791752.
  • Suntres ZE. Liposomal Antioxidants for Protection against Oxidant-Induced Damage. Journal of Toxicology 2011 May 24. Article ID 152474.
  • Topham NJ, Hewitt, EW. Natural killer cell cytotoxicity: how do they pull the trigger? Immunology. 2009 Sep. PubMed PMCID: 2747134.

Setria® is a registered trademark of Kyowa Hakko USA, Inc.

© 2014 LivOn Labs

4 Responses to Study Shows Daily Supplementation of Setria® Glutathione Increases Glutathione Levels in the Body

  1. Rachel says:

    Hi I wanted to find out if Liposomal GSH + VitC can help with skin conditions and lightening sun burned skin over a period of time, IV infusion have proved to be effective and ive seen proof of that in our local skin care clinic where clients skin becomes lighter and lighter, how does this happen i know it inhibits melanin but i wanted to find out how can lipoGSH help and at what dose?

    • Felipe Gonzales says:

      Glutathione and Vitamin C are well known for having a positive impact on the health and appearance of skin. Free radicals can have a negative impact on the skin, and as antioxidants, Vitamin C and Glutathione are able to protect the cells from the damaging effects of free radicals (including increased production of melanin). We have not conducted any studies on skin lightening specifically with the Lypo-Spheric Glutathione, but we have received testimonials from customers who have seen positive results with their skin. We recommend starting with a dose of 1 packet (450 mg Glutathione) per day. Please note it can take 4 weeks or more to see an improvement in the skin. It is best to take the product consistently, and drink plenty of good-quality water.

  2. Mary B. Tkach (aka Mary B.) says:

    I’m very interested in receiving any and all clinical or whatever studies have been done re Glutithione as I’m trying to get the Pharmacy here in the Cayman Islands to carry it and, so far, I’ve just given them an article I saw in “Women’s World” or whatever so any and all medical reports etc. would be greatly appreciated. I’ve purchased Glutathione, Vit C etc. from you under my married name of Mary B. Bodden and shipped to Toronto, Canada, but I prefer to use my maiden name now and you could mail out this information to me at Grand Cayman e.g.

  3. Sam Wolf says:

    I would like to ask where you procure your Vitamin C. There has been talk about Vitamin C from China that is of unknown standard.

    some websites state specifically that their vitamin C is made under proper supervision.

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