Category Archives: Glutathione

What is Glutathione (GSH)?


If you’re reading this, odds are you have seen the term “Glutathione” (GSH) before. But how much do you know about this powerful antioxidant? Do you know that it has been touted as the “next big antioxidant” or “the master defender” by health professionals world wide? If not, listen up.

Glutathione offers countless benefits related to joints, eyes, the brain and lungs. Yet, market research suggests that fewer than 6% of consumers are familiar with it. How could this be?

GSH is the most prevalent antioxidant produced by the human body. Healthy cells actually produce Glutathione. When cells run out of GSH, they die! GSH production naturally declines with age. So, supplementation of this vital antioxidant is paramount.


  • Helps protect cells from the damage caused by harmful free radicals
  • Promotes detoxification and optimal cellular health
  • Supports a healthy liver and immune system

Glutathione deficiencies have been linked to many chronic, difficult to treat illnesses. (Here is your chance to start that online search we mentioned earlier!). In addition to its powerful effects inside the body, Glutathione has been used for decades all over the world to improve skin clarity, tone and texture.

A study published in the European Journal of Nutrition revealed that daily supplementation of Setria® Glutathione – the form of L-Glutathione used in Lypo-Spheric™ Glutathione – is effective at increasing body stores of Glutathione by 30-35% over a 6 month period.

It’s probably time for you to give Gluathione a try. With our 100% money back guarantee, what have you got to lose?

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Study Shows Daily Supplementation of Setria® Glutathione Increases Glutathione Levels in the Body

glutathione supplement

A new study published in the European Journal of Nutrition revealed that daily supplementation of Setria® Glutathione – the form of L-Glutathione used in Lypo-Spheric™ GSH – is effective at increasing body stores of glutathione by 30-35% over a 6 month period.

The randomized, double-blind, placebo-controlled trial was conducted at Penn State University School of Medicine and lead by Dr. John P. Richie, Jr., Ph.D., Professor of Public Health Sciences and Pharmacology. Dr. Richie has studied glutathione for more than 25 years, focusing primarily on glutathione’s ability to fight oxidative stress.

“It is well-known in the science community that glutathione is one of the primary protective molecules in the body; however, whether or not glutathione levels could be supplemented by oral glutathione administration has been hotly debated and clinical data has been lacking,” said Dr. Richie. “Now we have evidence to illustrate the potential benefit of glutathione supplementation …”

The study measured the effect of supplementation with Setria® Glutathione on glutathione levels in 54 healthy adults, 28-72 years of age. One group of subjects took 250 mg/day (low-dose), the second group took 1,000 mg/day (high-dose), and the third group took 470 mg/day of placebo. Glutathione levels were measured over a six month period in different blood components, including erythrocytes (red blood cells) and lymphocytes (white blood cells), as well as the buccal mucosal cells that line the inside of the cheeks.

Results of the study showed glutathione levels in the blood increased after one, three and six months when compared to baseline levels at both doses.And at six months, average glutathione levels increased 30-35% in erythrocytes, plasma, and lymphocytes, and 260% in buccal cells in the high-dose group.

In addition to the increase in glutathione levels, the study showed that daily supplementation of 1,000 mg/day enhanced the function of natural killer (NK) cells more than two fold after three months. NK cells are vital to a well-functioning immune system because they can rapidly identify and kill abnormal cells. This two fold increase in NK cytotoxicity means the NK cells were two times as effective at killing abnormal cells, such as cells that are virally infected or tumorigenic.

A secondary endpoint analysis of the data also indicated that daily supplementation of 250 mg – 1,000 mg of Setria® Glutathione may result in a significant decrease in oxidative stress after 6 months. While the majority of glutathione in cells is in the reduced form (the “active” form), it becomes oxidized when it is used to neutralize free radicals and other toxins that cause oxidative stress.  So as oxidative stress increases, the level of oxidized glutathione in the body increases, and the level of reduced glutathione in the body decreases. Therefore, a reduction in oxidative stress was demonstrated with a decrease in the ratio of oxidized to reduced glutathione.

Why is all of this data important?

Glutathione is often called the “Master Defender” due to its vast functions as an antioxidant, detoxifier and immune system supporter. It is found in nearly all cells, tissues and organ systems in the body. Our bodies produce glutathione naturally, but everyday factors including the intake of medication, ill health, exposure to environmental toxins, aging and diet dramatically reduce the body’s stores of glutathione. As glutathione levels decrease, a detrimental drop occurs in the cellular functions that help maintain a healthy heart, brain, eyes, liver, kidneys, pancreas, and joints.

Previously, the only reliable way to boost glutathione levels was with IV infusions. With Setria® Glutathione and the superior bioavailability offered by liposome-encapsulation, this is no longer the case. Orally-ingested Lypo-Spheric™ GSH combines Setria® Glutathione with Liposomal Encapsulation Technology to protect the glutathione from being destroyed in the digestive system, making Lypo-Spheric™ GSH an efficient and cost-effective way to boost glutathione levels.


  • Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD, Muscat JE. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2014 May 5. PubMed PMID: 24791752.
  • Suntres ZE. Liposomal Antioxidants for Protection against Oxidant-Induced Damage. Journal of Toxicology 2011 May 24. Article ID 152474.
  • Topham NJ, Hewitt, EW. Natural killer cell cytotoxicity: how do they pull the trigger? Immunology. 2009 Sep. PubMed PMCID: 2747134.

Setria® is a registered trademark of Kyowa Hakko USA, Inc.

© 2014 LivOn Labs

Glutathione (GSH) and Electron Flow

GSH and Cellular Health. Glutathione (GSH) is so important to the health of every cell in the body that cells die, when GSH levels inside cells drop too low 1.  It is at this very cellular level where most of the battles against toxins, pathogens, free-radicals, and aging are won or lost.

Even without the extra toxic demands exerted by 21st century living, the requirement for GSH production is high. Immune system cells like mast cells and white blood cells, as well as organ tissues – most notably the brain, heart, lungs, liver, and eyes – depend on GSH for survival. Healthy, unchallenged cells can produce a sufficient amount of GSH for a host of protective (see Table 1.1) and metabolic (see Table 1.2) functions. When additional pressures ensue — like emotional and physical stress, radiation, infection, an unhealthy diet, toxins, heavy metals, and the invasion of pathogens — cellular levels of GSH can be quickly depleted.

Table 1.1 Cell-Protective Functions of GSH
Neutralization and reduction of various toxins and carcinogens
Protection against intracellular oxidative damage
Enhancement and support of the immune system

As long as sufficient quantities of it are present, GSH effectively defends the cell’s DNA, membranes, nucleus, and other organelles by neutralizing this continuous oxidative stress. When GSH is depleted, however, cellular damage can be expected.

Table 1.2 Cell-Metabolic Functions of GSH
Facilitating DNA synthesis and repair
Facilitating protein and prostaglandin synthesis
Facilitating amino acid transport across cell
Activation of enzymes (includes glutathione reductase, glutathione peroxidase, and glutathione S-transferase) Czeczot 2006

The Miraculous GSH Molecule

The unique molecular characteristics of GSH account for its vast range of functions. In addition to its role as an electron donor (antioxidant), GSH also joins with a large number of different compounds to form complexes (conjugates) with very special properties. This conjugating ability allows GSH to function as a:

  • potent antioxidant
  • powerful detoxifier as the primary participant in the neutralization and/or excretion of many toxins
  • “Super food” for the immune system including B-cells, T-cells, mast cells, phagocytes, and macrophages
  • intracellular source of organic sulfur
  • cofactor for the function of different critical enzymes
  • participant in maintaining integrity of protein’s critical disulfide bonds
  • transporter of amino acids across cell membranes
  • DNA synthesis and repair
  • protein synthesis
  • electron exchanger in many redox reactions

Electron Flow: Key to Continuous Intracellular Defense. The amazing power of GSH, in large part, lies in its ability to promote a healthy flow and supply of electrons within each cell in the body. Even though it is not possible to take a teaspoon of electrons, one can ingest medications and/or nutrients that are extremely rich in their electron content. Once a sufficient quantity of electrons is delivered to the body, it brings about what can only be described as fantastic results.

For more information on Glutathione, read Dr. Thomas Levy’s book GSH Master Defender.


Beaver 1995, Ghibelli 1998, Hammond 2004, Franco 2006

What is Reduced Glutathione?

Anyone who has seen iron or steel “rust” has seen the results of oxidation. It is a well-known example of oxidation, and oxygen is actually the culprit in rust, scientists continue to use the term “oxidized” to describe a molecular process which does not always involve oxygen.

Electrons are small, negatively charged particles that orbit the nucleus of the cell. Sound familiar from grade school? Never though this would have been useful in the real world but it is. Each atom has a nucleus which contains positively charged protons and usually neutrally charged neutrons.diagram of an atom

When the number of protons and electrons are equal, the net electrical charge is zero and the molecule is in a stable state. When a molecule has fewer electrons than protons, the net charge is positive and is considered “oxidized”. Oxidized molecules are unstable and seek sufficient electrons to become electrically neutral. These aggressively active molecules are known as free radicals.

Reduced Glutathione

Substances such as vitamin C, in the oxidized state no longer function as an antioxidant. Only when they are reduced, meaning they contain needed electrons, can they effectively function as antioxidants. To learn more about free radicals and Glutathione (GSH). See Dr. Thomas Levy’s book GSH Master Defender Against Disease, Toxins, and Aging.

Boost Cellular Levels with GSH

Boosting cellular levels of GSH can provide you with a host of benefits, including:

  • Promotes detoxification of harmful toxins*
  • Helps protect the body from the damage caused by free radicals*
  • Recycles vital antioxidants like Vitamin C and Vitamin E*
  • Supports a healthy immune system*
  • Supports a healthy liver*
  • Improves overall feelings of well-being*

LivOn Labs’ Lypo-Spheric GSH is

  • ✓ Up to 98% Bioavailable
  • ✓ 100% non-GMO
  • ✓ Gluten-Free

Intravenous injections of GSH can cost as much as $900 per injection, and require trained medical staff to administer the injection. A packet of LivOn Labs’ GSH costs less than $2!

Why Do You Need Glutathione?

Every cell in the body needs GSH. In fact, when a cell loses its GSH, it dies! Researchers report that physical and emotional stress, pathogens, toxins, free-radicals and aging – all of these factors, separately and together – can significantly reduce and even totally deplete intracellular levels of GSH.

The Lypo-Spheric GSH Difference

Typical oral GSH supplements encounter one major problem: digestive juices destroy glutathione. Until recently, the answer has been to take GSH precursor supplements or go to a medical office for painful, expensive intravenous injections of GSH.

GSH precursor supplements – the ones that are merely GSH building blocks – depend on cells to reconstruct GSH once the building blocks arrive in the body. Truth is, reconstruction is not guaranteed. This process requires circumstances and energy that are often lacking in the cells and tissues that are deficient in GSH.

The liposomes in Lypo-Spheric GSH are made from phospholipids high in PC, PE and PI. They are strong enough and smart enough to protect GSH from digestive juices and slip right into the bloodstream. From there, the liposome takes the GSH right into the cell where it’s needed the most.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

GSH: Unmatched Protection for Vital Organs

GSH is a powerful antioxidant, that’s been established. But did you know it has the properties to protect vital organs?

GSH: protects, feeds the brain

gsh brain
The requirement for GSH is especially high in brain cells. Countless studies show oxidative stress in brain neurons is present in virtually every brain and mental disorder.  For example, research concludes low or depleted GSH levels play a primary role in the onset and evolution of Parkinson’s disease and also shows Alzheimer’s disease is always associated with a depletion of GSH and other antioxidants in neuronal cells.

GSH: guards, fuels the heart

liver and gsh levelsGlutathione serves many functions that are essential for heart health. It helps activate and regulate enzymes. GSH transports amino acids and participates in protein synthesis that is required for muscle maintenance and repair.  Its role in energy production and delivery to this muscle that contracts almost a million times per year is tantamount. And GSH’s role as a detoxifier and antioxidant helps protect the heart from damaging attacks from free radicals and toxins.

Depleted GSH levels in the heart are related to irregular heart beat and high blood pressure.  In addition, GSH levels in blood are used as a direct, independent marker of oxidative stress in heart failure patients.  Studies show that GSH’s role in heart health is so dramatic that maintenance of adequate GSH levels can substantially reduce oxidative stress damage after a heart attack.

GSH: defends the lungs

Because of the lung’s role in providing oxygen to the body, it is under constant attack from oxidative stress and from airborne pathogens.  Lung disease researchers consider GSH to be one of the most important antioxidants in the human lung and lung secretions.

Low GSH levels in the lungs leave them vulnerable to disease and damage and also result in decreased exercise tolerance. GSH status in the lungs is a clear indicator of lung health. The higher the levels, the healthier the lungs.

GSH: protects, sustains the liver

liver and gsh levelsThe liver’s continual exposure to free radicals and toxins substantially increases its need for high levels of GSH. Low and depleted levels are found in those with chronic liver disease and liver damage. Studies prove that healthy and ailing livers significantly benefit from improved GSH function and overall antioxidant capacity.

What does GSH and a Battery Have in Common?

GSH and a BatteryLike a flashlight battery, the power of antioxidants is found in their ability to supply a steady flow of electrons. When a flashlight battery is fresh, the flow is strong and the light is bright. As the battery is used and depleted, the flow diminishes and the brightness of the flashlight dims. At some point the flow stops and the battery is deemed to be “dead”.

Similarly, in the human body a strong flow of electrons means good health, a weak flow of electrons means sickness, and cessation of electron flow results in death.

So let’s review




GSH provides a robust flow and supply of electrons throughout the body and particularly in the body’s individual cells. This flow is essential for achieving and maintaining optimal health through equipping the body to fight disease, disarm free radicals and neutralize toxins. GSH is so suited for supplying electrons that it actually “recharges” other antioxidants like vitamin C, vitamin E, alpha-lipoic acid, and sodium oxide dismutase (SOD).

What’s Known About the Power of GSH

With all the attention from researchers, we now know…

  • GSH provides unparalleled immunity-supporting and life-enhancing capabilities within each cell of the body.
  • GSH is one of the most important and concentrated intracellular antioxidant.
  • GSH is essential for the delivery of life-sustaining energy throughout each cell in addition to acting as the major protector for the mitochondria (the cellular energy plants).
  • GSH is the most potent intracellular detoxifier.
  • GSH is required for enzyme activation and enzyme regulation, amino acid transport, and protein synthesis -including the synthesis of DNA and RNA.
  • GSH is the primary antioxidant “recharger” in the cell -recharges vitamin C, vitamin E, alpha-lipoic acid, and other antioxidants.

GSH levels are so tied to life and health that GSH levels are routinely used to monitor the health status of those with life-threatening immune diseases like HIV/AIDS and in determining lung health.

GSH: the Vital Longevity Molecule

GSH is intrinsically linked to the life of every cell. So linked that depleted GSH levels ALWAYS precede cell death. In other words, cells with adequate supplies of GSH do not die.  Researchers also observe, without exception, GSH levels drop in all bodily tissues as the body ages.

The reverse is true as well. Simply by boosting GSH levels, scientists have used GSH to dramatically extend animal life spans from insects to mammals.  The longevity increase is due in large part to the leading role GSH plays in the delivery of intracellular energy. In addition, GSH also provides essential support to each cell’s nucleus, mitochondria, DNA and membranes to keep cells functioning optimally.


Scientists/Medical Researchers Extolling the Merits of GSH (Glutathione)

The human body is composed of over 10 trillion microscopic cells. Because these building blocks are invisible to the naked eye, we tend to overlook an important reality: your overall health and longevity is dependent upon the life, health, and energy status of the individual cells that make up your body.

Although a vast array of molecules must work together in each cell to keep it alive and functioning, one molecule in particular -Glutathione Sulfa-Hydryl (GSH) is easily declared “most valuable”.

Over 80,000 peer-reviewed studies have been indexed for Glutathione (GSH) by the Federal Government’s National Institute of Health for its Pub-Med library.

And volumes have been written about GSH with titles like:

  • Glutathione: The Ultimate Antioxidant by Alan Pressman and Sheila Buff
  • The GSH Phenomenon: Nature’s  Most Powerful Antioxidant and Healing Agent by Alan H. Pressman and Sheila Buff
  • New Hope for Serious Diseases: The Healing Power of Glutathione by Howard Piper
  • Glutathione (GSH): Your Body’s Most Powerful Healing Agent by Jimmy Gutman and Stephen Schettini
  • Glutathione and Sulfur Amino Acids in Human Health and Disease by Roberta Masella and Giuseppe Mazza
  • GSH: Master Defender by Thomas E. Levy, MD, JD

In addition to those listed above, a recent search at on the keyword “Glutathione” lists over 15,000 books and articles.

To read more about the amazing benefits of GSH visit these websites.