Category Archives: R-ALA

Liposomal Alpha Lipoic Acid Benefits and Facts

Here is a quick list of Alpha Lipoic Acid benefits and facts. LivOn Labs has successfully encapsulated Alpha Lipoic Acid (R-ALA) and we are excited to tell you all about it!

  • Also known as: Thioctic acid, Lipoic Acid, LA, ALA
  • ALA was discovered in 1948 and officially named Alpha Lipoic Acid in 1951 by Irwin C. Gunsalus and Lester Reed
  • ALA is naturally synthesized in small amounts by plants and animals, including humans.
  • ALA contains an asymmetric carbon, meaning there are two possible isomers: R-LA and S-LA. Only the R- isomer is endogenously synthesized and bound to protein. R-Alpha Lipoic Acid is considered the most bio-available and biologically active form of ALA in the body
  • Alpha Lipoic Acid is a vital cofactor for several important mitochondrial enzyme complexes.
  • The amounts of R-ALA available in dietary supplements are as much as 1,000 times greater than the amounts that could be obtained in the diet.  Animal tissue that includes R-ALA include liver, heart and kidney. Plants with R-ALA include spinach and broccoli, tomatoes, peas and Brussels sprouts.
  • Plasma concentrations of ALA generally peak in an hour or less and decline rapidly.
  • In cells, ALA is quickly reduced to DHLA.
  • ALA functions as an antioxidant.
  • ALA is considered the most important mitochondrial antioxidant given its vital role in mitochondrial electron transport reactions that convert glucose into ATP to produce energy.
  • Recycles other antioxidants, including vitamin C and vitamin E.
  • Shown to increase natural glutathione synthesis in aged animals.
  • There is no documented “nutrient deficiency” disease associated with ALA.
  • Intravenous ALA is approved for the treatment of diabetic neuropathy in Germany. R-ALA is available by prescription in Germany.  Dosage used in a trial with 1,258 diabetic patients found that a treatment of 600mg/day if IV R-ALA for 3 weeks significantly reduced the symptoms of diabetic neuropathy to a clinically meaningful degree.[1]
  • R-ALA should always be taken on an empty stomach.
  • Most frequently reported side effects of oral ALA supplementation include rashes, hives, itching, abdominal pain, nausea, vomiting and diarrhea. These generally occur when supplementing at doses of 1,200 – 1,800 mg/day.
  • ALA should be taken under the guidance of a physician by anyone taking glucose lowering medication or receiving treatment for under-active or over-active thyroid.
  • ALA should not be taken by children under the age of 18, unless under the care of a physician.
  • “Without ALA, you could not obtain energy from the food you eat, and you could not stay alive.” Burt Berkson, MD, MS, PhD

[1] Ziegler D, Nowak H, Kempler P, Vargha P, Low PA. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis. Diabet Med. 2004;21(2):114-121.  (PubMed)

Identifying High-Quality Liposomal Supplements

We have spent years researching the best formulation techniques and manufacturing processes for liposome encapsulated supplements. As part of this research, we analyze every liposomal supplement we come across.  This is what we’ve learned so far…

Liposomal Supplements Must Use Phospholipids Suitable for Making Liposomes.

In order to make strong, stable liposomes that can encapsulate nutrients and not “break apart” too easily, it is important to use Phospholipids from highly refined sources that have a natural mix of phospholipids, including a high percentage of Phosphatidylcholine (PC) and Phosphatidylethanolamine (PE).

Some products are made with low-quality soy lecithin, which does not have the proper percentage of PC or PE to make liposomes.  This type of lecithin is typically used as a food additive, and should not be used in liposomal supplements.

We have always found that Phospholipids extracted from non-GMO soy lecithin work the best for high-quality, affordable liposomal supplements.  While a very high intake of unrefined soy ingested as food may contain tiny amounts of undesirable substances, the intake of highly refined and purified phospholipids derived from soy lecithin does not pose such a risk. In fact, we have not found any evidence of anyone being harmed by the regular intake of phospholipids extracted from non-GMO soy lecithin.

 Liposomal Supplements Must Have at Least an Equal Ratio of Phospholipids to Key Nutrients.

We have analyzed many commercial and homemade products, and found that most of them are of poor quality. Some are merely emulsions.  This means the nutrients are simply mixed with a small amount of low quality phospholipids or lecithin, and there are very few liposomes, if any at all.

One indicator of an emulsion is the amount of phospholipids or lecithin in the product.  For proper liposome encapsulation, you must have at least an equal amount of phospholipids and nutrients.  If the phospholipids or lecithin are listed as “Other Ingredients”, it is very likely there is not enough material to create any liposomes, even if the production process is otherwise appropriate.

Some companies choose to make emulsions and call them “Liposomal Supplements” because they are easy and inexpensive to produce.   Whether they believe they have products that are legitimately encapsulated in liposomes is unknown.

If you take an emulsion that contains lecithin and a nutrient like vitamin C, you may see overall good results since both components are excellent supplements individually.  You will not, however, be able to experience the potentially exceptional results offered by products using real Liposome Encapsulation Technology.

Liposomal Supplements Must Be Protected from Oxygen.

Liposomes are a natural fit for water-soluble nutrients that are not otherwise bioavailable.  But the process of making stable, quality liposomes is tricky.  Liposomes are sensitive to things like heat and oxygen.  The inherent stability (and in some cases instability), of the phospholipids and each nutrient also play an important role in the overall stability of liposomal products.  Getting all of these things exactly right, then assuring the liposomes and nutrients remain stable throughout the product’s shelf life is key.

One way to enhance the stability of a liposomal product is through uni-dose packaging.  Many of the liposomal products we have analyzed are stored in jars, plastic bottles, or even capsules within bottles.  Opening the bottle to remove the product exposes the remaining product to heat, light and oxygen.  This can be detrimental to the liposomes, and can cause rapid degradation of the nutrients.

Uni-dose packaging protects the product from oxygen until moments before it’s consumed, keeping it safe and effective throughout the shelf-life of the product.

 Three More Signs of a Low-Quality Liposomal Supplement:

  1. Consistency. If the product is very watery, it is most likely due to an insufficient amount of phospholipids or the use of low quality phospholipids.
  2. Uniformity. If the product separates into layers, it is a strong indicator the liposomal mixture is deteriorating. On the other hand, if there are noticeable lumps or the product feels gritty, it is a sign that the nutrients are coming out of the liposomes and forming crystals.
  3. Size. If the volume of the dosage is too small, there are not enough phospholipids and water to make proper liposomes.  For example, 1,000mg of vitamin C and 1,000mg of phospholipids, along with the necessary amount of water for proper liposome formation, will fill a teaspoon (5mL).  It is not likely this amount of material could fit into one or even two large-sized capsules.

The Bottom Line

There are a plethora of liposomal supplements to choose from.  Some are great, many are not.  The key is finding the liposomal supplements that work best for you – from a company you can trust. LivOn Labs offers a 100% Lifetime Satisfaction Guarantee so you can try the Lypo-Spheric™ products for yourself.  If you are not satisfied, at any time, return the unused portion – or even the empty carton – and we will refund every penny you paid.

Pure & Powerful… Lypo-Spheric Supplements

What makes Lypo-Spheric™ products unique? Each Lypo-Spheric™ product is formulated with one goal in mind: to provide you with effective doses of nutrients without the use of binders, fillers, artificial colors or artificial flavors.

The nutrient-filled liposomes in each Lypo-Spheric™ product are small enough – and smart enough – to bypass the body’s restrictive nutrient transport system, and quickly pass through the intestinal wall and into the bloodstream. Within minutes of taking a Lypo-Spheric™ product, millions of liposomes will start to move from your bloodstream and into your cells – intact, and ready to work.

Our single-dose packaging protects the product from additional oxygen and moisture, which keeps your product fresh.

LivOn Labs’ products are sugar free, caffeine free, dairy free, meat free and gluten free.

We source ingredients from all over the world so we can use high-potency, non-GMO ingredients from natural sources whenever possible. We now guarantee that our Lypo-Spheric™ Vitamin C, Lypo-Spheric™ R-ALA and Lypo-Spheric™ GSH are 100% non-GMO.

EXTENDING THE SHELF LIFE….

The shelf life on the majority of our nutritional supplements is 12-18 months. To extend the shelf life we recommend refrigeration for maximum effectiveness. Do not freeze or place the products in direct sunlight for extended periods of time.